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J Card Surg, 18(6), 500-503

We would not expect a close match to the clinically observed percentage changes because we are comparing intracellular model changes to blood measurements

In addition to systemic toxicity caused by chemotherapy, systemic administration of ADCs can introduce toxicity from the antibody components, inducing immune responses and causing severe secondary injuries that lead to nephrotoxicity in patients 19

Pharmacovigilance analysis identified that patient age and body weight were significantly associated with gastrointestinal adverse event severity, with patients over 100 kg showing stronger signal strength for adverse events