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Zhang WQ, Xue JD, Ge M, Yu ML, Liu L, Zhang ZG

Iron and copper: critical executioners of ferroptosis, cuproptosis and other forms of cell death

It is not yet well-understood how these bacteria can exert these benefits, but documented mechanisms of action include antimicrobial activity against major gastrointestinal 171 and urogenital pathogens 172 , barrier-promoting effects at the gut epithelium 173 and other mucosa 174 , immunomodulatory effects by stimulating host antimicrobial compounds such as - defensins 175 and modulating the secretion of cytokines such as IL-10, IL-6, IL-1b, IL-2, TNF-, and impacting different cell types such as intestinal epithelial cells, dendritic cells, macrophages and regulatory T cells 176,177,178

Koutroubakis IE

Kimura M, Toyoda M, Gojo S, et al