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Funding This work was supported by National Institutes of Health Grants NIEHS R01 ES024756 (to EL), R01 ES031282 (to EL), R01 ES010563 (to MA), and NIMHD U54 MD007582

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When mitochondrial respiration is impaired in T cells, a metabolic shift toward glycolysis occurs, accompanied by accumulation of tricarboxylic acid cycle intermediates such as succinate

It's used traditionally in Japan and can be found naturally in a couple of plants , including the leaves of pear trees, wheat and bearberry

doi:10.1007/s10815-017-1032-1