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Over-expression of PDSS2 in human coronary artery endothelial cells (HCAECs) inhibited ROS release and iron content to suppress ferroptosis and promote the proliferation of HCAECs

The NO-mediated inhibition of sarco/endoplasmic reticulum calcium ATPase pumps was believed to facilitate sustained calcium release, thereby increasing cytosolic calcium concentrations and cross-bridge formation (Xu et al., 1999)

Most of the evidence giving rise to this claim comes from a few observational studies

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Spermidine levels decline progressively with age and are closely associated with the development of age-related diseases