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doi: 10.1182/asheducation.V2012.1.301.3798316 81 BaldovinoSMontinDMartinoSSciasciaSMenegattiERoccatelloD

At the same time, excessive ROS accumulation activates inflammatory/immune responses through signaling pathways such as NF-B, MAPK, and STAT3, resulting in increased expression and secretion of pro-inflammatory cytokines

Once a lesion has been excised and confirmed as a benign melanotic macule on microscopy, recurrence is uncommon and there is no long-term health implication

[28] VMI is determined using a specific formula and provides a more comprehensive view of the hormonal effects on the vagina over time than a single hormone level measurement

Acknowledgements This work was supported by Fondazione AIRC (Associazione Italiana per la Ricerca sul Cancro) Grant IG20801 and IG29329 to L.D.M., MFAG 2021-ID 26536 to P.I