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Clinical trials indicate bethanechol is no more effective than placebo, and its use is associated with significant dose-dependent unpleasant side effects including blurred vision, bradycardia, bronchospasm, and GI upset (Barrett 1981

Several ozone therapy clinical trials are in progress for conditions from heart disease to arthritis

Unlike exogenous antioxidants derived from fruits and vegetables, glutathione is synthesized in liver cells

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AUD alcohol use disorders BHB -hydroxybutyric CPP conditioned place preference DA dopamine DUD drug use disorders GABA -aminobutyric acid IL interleukin KD ketogenic diet MOR mu-opioid receptor NAc nucleus accumbens NLRP3 nucleotide-binding domain-like receptor protein 3 ROS reactive oxygen species SUD substance use disorders TNF tumor necrosis factor Abbreviations References 1