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While iron accumulation and redox imbalance can promote genomic instability and tumor growth, they also create conditions that sensitize cancer cells to ferroptosis ( Inducing ferroptosis has emerged as a promising strategy to overcome resistance to chemotherapy and targeted therapies

Inhibition of glutaredoxin 5 predisposes cisplatin-resistant head and neck cancer cells to ferroptosis

Aging Dis 13:491

The highest incidence, 49.8%, was observed in children with IFALD, and it can rise to as high as 90% in preterm infants receiving parenteral nutrition for more than 90 days [75]