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Since tirzepatide already activates the GLP-1 receptor along with the GIP receptor, combining it with semaglutide could overstimulate these pathways

For instance, serous carcinomas, the most common subtype, often exhibit higher ER and PR expression levels [128]

Consequently, A2AR blockade enhances T cell effector function while inducing ferroptosis due to increased lipid peroxidation, which provides a mechanistic explanation for the recent observations of decreased survival of tumor-infiltrating A2AR-deficient T cells (46) or activated CD73-deficient CD8 + T cells under antigenic stimulation (47)

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