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Once activated, TGF- binds to its receptor complex, initiating phosphorylation of Smad2 and Smad3, which then form a complex with Smad4 and translocate to the nucleus and regulate gene transcription (70)

Discussion Identification of protein interactions is a strategy used to predict the functions of an unknown protein, to explore a novel role for a known protein in cellular processes and to identify a new member of protein complexes 17

Ferulic acid alleviates alveolar epithelial barrier dysfunction in sepsis-induced acute lung injury by activating the Nrf2/HO-1 pathway and inhibiting ferroptosis