impaired glutathione synthesis b12 Vitamin deficiency results in severe oxidative stress, leading to memory retention impairment in Caenorhabditis elegans Glossitis and hyperpigmentation of hands
Glossitis and hyperpigmentation of hands due to Vitamin B12 deficiency. B12 leads to melanin synthesis more frequently in people with darker skin. Skin hyperpigmentation was reversed with B12 replacement Vitamin B12: prevention of human beings from lethal diseases and its food application Harikrishnan 2025 Journal of the Science of Food and Agriculture Wiley Online Library Pernicious Anemia and B12 Deficiency PlexusDx Full article: Causes and consequences of impaired methionine synthase activity in acquired and inherited disorders of vitamin B12 metabolism One carbon pathway and cognitive skills in children with Down syndrome Scientific Reports
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