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Description

The KYN pathway serves as the primary metabolic route for tryptophan, facilitating its involvement in the TCA cycle and the production of NAD+ [25]

A., Diep, L

2013;2(10):e126

Y., and Gladyshev, V

However, activation of the IKK kinase complex results in IB degradation, facilitating NF-B nuclear translocation and upregulation of pro-inflammatory genes, including Interferon gamma (IFN-), transforming growth factor beta (TGF-), interleukin (IL)-1, monocyte chemoattractant protein 1 (MCP-1), IL-6 and TNF-