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Impact of the Pd2Spermine Chelate on Osteosarcoma Metabolism: An NMR Metabolomics Study

Here we have identified that depletion of -ketoglutarate (KG) sensitizes HR-proficient cells to DNA-damaging agents by metabolic regulation of histone acetylation

The + 4-oxidation state of Mn in MnO imparts strong oxidative properties, enabling its responsiveness to reducing agents like GSH, allowing it to be rapidly reduced and degraded by GSH