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The signal peptide is cleaved in the lumen of the rER by a signal peptidase (located on the lumenal side of the rER membrane)

Stable abnormal N-heterocyclic carbenes and their applications

During the oxidation phase, accumulated ROS (such as hydrogen peroxide HO and superoxide anion O) in the cell can directly react with GSH in a non-enzymatic manner, or, under the catalysis of glutathione peroxidase (GPX), promote the oxidative coupling of two GSH molecules to form one molecule of GSSG, while releasing two protons (H) and two electrons (e)

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Without a loading dose, it would take months to achieve a therapeutic effect, which is likely clinically unacceptable