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From inflammation to depression: key biomarkers for IBD-related major depressive disorder

In a rat model, melatonin demonstrated inhibition of NMDA receptor activation and subsequent NMDA receptor-mediated Ca 2+ entry into striatal neurons, suggesting a potential protective role [79]

Four PK isoenzymes are present in mammalian tissues: PK-M1 (in skeletal muscle), PK-M2 (in leukocytes, kidney, adipose tissue, and lungs), PK-L (in liver), and PK-R (in red blood cells)

Patients with pre-existing hypovolemia or hypotension should have their condition corrected before diuretics are initiated

339 In addition to the changes in lipid metabolism of immune cells, changes in lipid metabolism of the obese individual are also important for regulating immune cell activities