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[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Umar S., Lee J.H., de Lange E., Iorga A., Partow-Navid R., Bapat A., van der Laarse A., Saggar R., Saggar R., Ypey D.L., et al

A deficiency in ACSL4 can lead to upregulation of MLKL expression, making cells more sensitive to ferroptosis (106)

When designing combination protocols, researchers should account for possible interactions, adjust doses, use enhanced safety monitoring, and include appropriate controls

Inhibiting NNMT may reduce fat storage and enhance fat metabolism, which would facilitate weight loss andmore importantlyallow for long-term fat loss

Ultimately, the integration of fundamental science, technological innovation, and clinical collaboration will establish ferroptosis as a cornerstone of personalized kidney disease management