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By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis and fat oxidation [3]

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NNMT inhibition plus a lean diet accelerates weight/fat loss, improves body-composition indices, and normalizes several liver pathologies versus diet alone [3,4]