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The double-blind study used an innovative strategy of including multi-modal measures of target engagement, including kappa opiate receptor occupancy, functional MRI and transcranial magnetic stimulation measure of cortical inhibition

Another peptide (Con-G) is directed towards the transport of KA to hippocampal and prefrontal cortical areas

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Depression, anxiety, and sleep disorders can be attributed to psychological stress and tension caused by the COVID-19 pandemic (Kubota et al., 2023)

Loss of NNT activity leads to a drop in NADPH levels which are required for ROS removal via glutathione