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Escudier S, Drach JW, Andreeff M

Ferroptotic and M1-type macrophages both exhibit iron accumulation

Adenosine monophosphate deaminase 3 null mutation causes reduction of naive T cells in mouse peripheral blood

Results: The core mechanism of MR lies in disrupting one-carbon metabolism and epigenetic regulation that rely on methionine, depleting the crucial metabolite S-adenosylmethionine (SAM), thereby inhibiting histone/DNA methylation, disrupting redox homeostasis, and ultimately inducing cell cycle arrest and apoptosis