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Senescent cells undergo profound epigenomic changes that distinguish them from both proliferating and quiescent cells ( In line with the mechanisms described above, recent studies on the epigenetic regulation of microglial senescence can be summarized as follows (Figure 5): global DNA hypomethylation (Cho et al., 2015

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MORE Type 1 diabetes mellitus (T1DM), also known as insulin-dependent diabetes, is a chronic disease caused by autoimmune (type 1a) or spontaneous (type 1b) destruction of pancreatic beta cells, resulting in insulin deficiency

The mitochondrial GSH pool is maintained in the reduced state by GR that couples GSSG reduction to the matrix NADP+/NADPH pool (Figure 3) [3,23]