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This is largely due to a lack of isoform specific inhibitors and activators and the need to target specific cells to avoid unintended effects

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For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses