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Retatrutide produced an average weight reduction of 24.2% at the 12 mg dose after 48 weeks in its Phase 2 obesity trial, according to Jastreboff and colleagues (NEJM, 2023

Interestingly, when 5-amino-1MQ was applied to HEK-293 cells, another widely used cell line in research derived from human embryonic kidney cells, there was no significant impact on their growth