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Cloudiness indicates protein aggregation peptide chains have clumped together due to temperature abuse, pH drift outside the neutral range, or bacterial contamination

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Int J Neurosci 119(6):821846 Suhner A, Schlagenhauf P, Johnson R, Tschopp A, Steffen R (1998) Comparative study to determine the optimal melatonin dosage form for the alleviation of jet lag

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As a result, first-line options might prioritize antidepressants that are less dependent on CYP2D6 metabolism, such as escitalopram or sertraline (with careful consideration of CYP2C19 status), or non-SSRI agents like desvenlafaxine (Lense et al., 2024)

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