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induce the activity of CREB (cAMP response element binding protein) and increase BDNF gene expression, which initiates pro-survival programs by reducing the expression of pro-apoptotic factors (Khacho et al, 2015)

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While metabolic remodeling has been extensively described in cancer, diabetes, mitochondrial diseases and autoimmune disorders (for review see 27 ), little information is available about this topic in neurodegenerative diseases such as ALS 28