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This helix forms a lid over the active site when the hydrophobic substrate binding site (H-site) is occupied but it is otherwise disordered

PMID: 40121575 Chin Med J (Engl) Skin-localized sympathetic nerve-keratinocyte crosstalk fuels psoriatic inflammation via neutrophil recruitment

Unlike its precursor, L-carnitine, ALCAR boasts superior bioavailability, readily crossing the blood-brain barrier to exert its beneficial effects within the central nervous system