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Aloe-emodin reverses adriamycin (ADR) resistance in MCF-7/ADR cells by inhibiting P-gp efflux, altering energy metabolism, and inducing autophagy while enhancing apoptosis via DNA damage, ROS generation, and Caspase-3 activation [504]

Abstract Cadmium is a highly neurotoxic heavy metal that disrupts membranes and causes oxidative stress in the brain

Journal of Neuroimmunology 195 , 8187 (2008)

The same legal limits, established as tolerance limits, also apply to imported food products to facilitate international trade

Phase II detoxification Conjugates with reactive metabolites (acetaminophen toxin, heavy metals) for excretion via the liver - a primary detox pathway