The guidelines specify that clinicians should not offer the following agents for prevention of peripheral neuropathy in cancer patients undergoing treatment with neurotoxic agents: Acetyl-L-carnitine (recommendation = strong against, with high strength of evidence, no evidence of efficacy, and high evidence of harm) Amifostine (recommendation = moderate against, with intermediate strength of evidence, low evidence of efficacy, and moderate evidence of harm) Amitriptyline (recommendation = moderate against, with intermediate strength of evidence, no evidence of efficacy, and moderate evidence of harm) Calcium and magnesium for patients receiving oxaliplatin-based chemotherapy (recommendation = moderate against, with high strength of evidence and low evidence of efficacy and harm) Diethyldithio-carbamate (recommendation = strong against, with low strength of evidence, no evidence of efficacy, and high evidence of harm Glutathione for patients receiving paclitaxel/carboplatin chemotherapy (recommendation = moderate against, with intermediate strength of evidence and low evidence of efficacy and harm) Nimodipine (recommendation = strong against, with low strength of evidence, no evidence of efficacy, and moderate evidence of harm) Org 2766 (recommendation = moderate against, with intermediate strength of evidence and low evidence of efficacy and harm) Retinoic acid (recommendation = moderate against, with low strength of evidence, low evidence of efficacy, and moderate evidence of harm) rhuLIF , or emfilermin (recommendation = moderate against, with low strength of evidence, no evidence of efficacy, and low evidence of harm) Vitamin E (recommendation = moderate against, with intermediate strength of evidence and low evidence of efficacy and harm
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Hydrogen peroxide is a necessary cofactor for thyroperoxidase, the enzyme participating in a final step of hormone production
This allows time for the peptide to take effect while still maintaining spontaneity
