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According to research, when cysteine residues are muted owing to external factors, the spatial structure of the BCRP protein changes, affecting its activity and function to overcome multidrug resistance and improve drug sensitivity ( 2.2 Redox altered transporter gene expression Studies have shown that redox regulation of drug efflux transporters can be carried out through multiple pathways, and several transcriptional pathways that regulate gene expression induced by environmental factors have been identified ( 2 O 2 (Terada et al., 2014)