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found that luteolin reduced oxidative stress and myocardial tissue inflammation, thereby improving myocardial function in rats with diabetic cardiomyopathy ( Agrimonia pilosa Ledeb (Rosaceae) alleviates oxidative stress injury through the c-Jun amino-terminal kinase (JNK)/PI3K/Akt pathway, reduces the expression and secretion of inflammatory cytokines while improving glucose metabolism, and alleviating fatty IR ( Citrus maxima (Burm.) Merr

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Chemosphere 135:713

Conversely, genetic knockdown of TXNDC12 enhances ferroptosis sensitivity, leading to increased lipid peroxidation both i n vitro and in vivo [134, 135]