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Cruz A, Mota P, Ramos C, Pires RF, Mendes C, Silva JP, et al

Importantly, along with other clock proteins, REV-ERB is subject to ubiquitin-dependent degradation by E3 ubiquitin ligases such as FBXW7 and UBE3A (Zhao et al., 2016), as discussed in more detail in Section 4 E3 ligases and deubiquitinating enzymes in circadian regulation. 2.3 Turnover of core clock proteins The timed degradation of core clock proteins by the ubiquitin-proteasome system ensures proper cycling between repression and activation within the feedback loop, maintaining clock period length

Moreover, they were capable of inducing T cell activation in lymph nodes through both the classical antigen presentation by cells and a unique "direct exosome interaction" mechanism (Fig