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Immunol 9, 202 (2018)

Lippincott, Williams and Wilkins, 145-157, 2003

Exposure of solvent accessible cysteines to a slightly alkaline subcellular milieu increases the probability for thiol ionization

97 Other promising investigational CRISPR-Cas9 based gene-editing medicines are currently being evaluated in Phase 3 pivotal studies for transthyretin amyloidosis associated cardiomyopathy and neuropathy (NTLA-2001) and hereditary angioedema (NTLA-2002)