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The common thread is that isotretinoin's metabolic footprint is wide, and the liver has limited reserve capacity to handle multiple concurrent stressors at typical therapeutic doses

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3 were initially assigned a role in maintaining GSH homeostasis ( Arabidopsis , mirroring the function of mammalian CHAC2 (Vernoux et al., 2000)

doi: 10.1371/journal.pone.0043699 Wong, Emily S

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