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This event is followed by the generation of ROS from the oxidation of FADH2 as induced by the demethylase, with consequent oxidation of nearby guanines (8-oxo-Gs) and recruitment of DNA repair enzymes (among which is APE1) that cause single-strand breaks in DNA and enable looping between the enhencer/promoter and the polyadenylation sites of the target genes, with productive transcription 140,141

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For severe darkening or when home treatments aren't effective, professional options exist

This powerful antioxidant works to detoxify the body, support liver function, and promote brighter, more radiant skin by reducing oxidative stress and encouraging healthy skin cell renewal

Ascorbic Acid The pure form of Vitamin C, though very unstable and irritable to the skin