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Accordingly, the existence of polymorphisms and the increased expression or activity of enzymes participating in one-carbon metabolism are considered markers for highly proliferative and aggressive cancer phenotypes and chemoresistance (57, 62, 63)

Cui J, Wang Y, Tian X, Miao Y, Ma L, Zhang C, Xu X, Wang J, Fang W, Zhang X

For example, even though trivalent chromium is beneficial to health, hexavalent chromium has been identified as a carcinogen, and if inhaled, it may cause lung cancer (Sun et al