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Spermatozoa generate ROS via two primary mechanisms: the plasma membrane and the mitochondria [98]

Therefore, to reduce the confounding effects, IGF-1 SDS has recently been established for the evaluation of IGF-1 levels 10,11,25

This occurs because the pituitary gland and adipose tissue are stimulated to produce androgens and luteinizing hormone, respectively, in response to increasing levels of androgens, which in turn heighten insulin resistance (IR) and hyperinsulinemia (Hg)