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Without enough B12, red blood cells are not as efficient in transporting oxygen to cells throughout the body, causing fatigue and muscle weakness

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NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure

Used 40% less B12 total, but his levels stayed way more stable (450 -550 pg/mL instead of swinging between 300-700 pg/mL), and those mid-week energy dips disappeared

Oct 2022;61(7):3731-3739