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VD plays an important role in cell proliferation and differentiation, neurotrophic regulation, neuroprotection, neurotransmission, immune regulation and neuroplasticity (83, 84)

Abuafy MP et al (2018) Supramolecular cyclodextrin-based metalorganic frameworks as efficient carrier for anti-inflammatory drugs

In HIPEC, the drugs are heated to improve both efficacy and penetration, making them more effective in killing cancer cells 22

Furthermore, previous studies showed Ca 2+ to partake in cellular quality control such as autophagy 133 , further tying the dysregulation of Ca 2+ signaling to the accumulation of protein aggregates