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As evidenced by James et al ., histology from the hyper pigmented area showed irregular epidermal atrophy, absence of basal orientation of epidermal cells, patchy pigmentation of the lower epidermis, and numerous pigment-laden macrophages in the upper dermis and increase of melanin in the basal layer

A comprehensive safety and tolerability study evaluated approximately 900 participants across six trials with the following protocols: Subcutaneous/Intravenous Protocols: Single doses ranging from 25 to 400 mcg/kg body weight were tested

Description Optineuron Ampoule of 3 ml Injection Composition (Each 3 ml contains): Thiamine Hydrochloride IP 100 mg (Vitamin B1 essential for nerve conduction and energy metabolism) Pyridoxine Hydrochloride IP 100 mg (Vitamin B6 supports nerve health, amino acid metabolism, and RBC formation) Cyanocobalamin IP 1000 mcg (1 mg) (Vitamin B12 crucial for nerve regeneration, myelin formation, and DNA synthesis) Riboflavine Sodium Phosphate IP 5 mg (Vitamin B2 supports cellular energy and tissue repair) Nicotinamide IP 100 mg (Vitamin B3 improves circulation, reduces inflammation, supports metabolism) D-Panthenol IP 50 mg (Pro-Vitamin B5 promotes tissue healing and reduces nerve inflammation) Benzyl Alcohol IP 0.9% v/v (Preservative to maintain sterility) Water for Injections IP q.s

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In PHN the nerve cells can get damaged leading to increased excitability and persisting pain