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Urea is synthesized in the liver via the urea cycle from toxic ammonia

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Notably, Ang-2 induced the upregulation of 2 -integrin on monocytes, which interacted with ICAM-1 expressed by endothelial cells and thereby facilitated the migration of monocytes, leading to accumulation of monocyte-derived macrophages in the TME (77)

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10.1016/j.freeradbiomed.2008.04.007 217

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