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Anti-doping laboratories have developed methods to detect these metabolites, extending the detection window to approximately 4 days in urine samples

The proposed mechanism behind this follows decreased bradykinin metabolism and its increased plasma levels, activation of soluble guanylate cyclase (sGC) upon bradykinin B 2 receptor activation with subsequent nitric oxide release and vasodilatation leading to the increased GLUT4 translocation in peripheral tissues (139)

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