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Description

(PubMed) Haag M

Tirzepatide (development code LY3298176) is a single engineered peptide a fatty-acid-modified 39-amino-acid molecule that acts as a dual agonist at two incretin receptors: the glucose-dependent insulinotropic polypeptide (GIP) receptor and the glucagon-like peptide-1 (GLP-1) receptor

MB treatment alters the expression of a subset of ECM proteins, including upregulation of elastin and collagen 2A1 Elastin, one of the most abundant ECM components in skin dermis, plays an important role in maintaining skin elasticity and resilience

Activation of these proteins usually increases oxidative stress and inflammation that, in turn, promotes RAGE expression in a positive feed-forward loop, contributing to chronic disease development 39,40,41