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Damage to the heart valves can take many forms, primarily narrowing (stenosis), leaking (regurgitation or insufficiency), or improper closing (prolapse)

Eur J Pharmacol 802:719 Niu T, De Rosny C, Chautard S, Rey A, Patoli D, Groslambert M et al (2021) NLRP3 phosphorylation in its LRR domain critically regulates inflammasome assembly