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ABCB7 exhibits an early pre-hydrolytic state with a sufficiently large cavity to accommodate the substrate prior to transitioning to an outward-facing release conformation

Hays KE, Pfaffinger JM, Ryznar R

For example, inhibition of ATR by M6620 significantly induces lung cancer cells harboring more than two micronuclei, eliciting cGAS-micronuclei interacting to activate immune responses and partially enhance the responses to immunotherapy [100]