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Description

MM is a hematological neoplastic disorder characterized by the accumulation of malignant plasma cells in the bone marrow, where the disease may cause complications that are often referred to as CRAB features (hyper-calcinemia, renal insufficiency, anemia and/or bone disease) or SLIM biomarkers (clonal bone marrow plasma cell percentage 60%

Only a small minority of MCAS patients will require a trial of omalizumab as illustrated in a recent case series where only 1 of 31 patients with idiopathic MCAS and 2 of 13 patients with clonal MCAS received it [19]