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doi: 10.3389/fimmu.2025.1536020 140 ZhangPWangYMiaoQChenY

A Comparative Risk Assessment of Burden of Disease and Injury Attributable to 67 Risk Factors and Risk Factor Clusters in 21 Regions, 1990-2010: A Systematic Analysis for the Global Burden of Disease Study 2010

doi: 10.22038/IJBMS.2017.9116

As such, interventions aimed to reduce SOD1 G93A expression and/or SOD1 G93A protein accumulation are most likely to achieve large rescuing effects in this model, whereas interventions that do not directly target the SOD1 G93A mechanisms are less likely to achieve success in retarding motor neuron disease of this model 23,24,25

456 Additionally, gene therapy approaches targeting defective genes associated with XLP1, FHL2, and FHL3 have shown encouraging results in preclinical mouse models, offering potential avenues for future curative treatments