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It is well established that T cells shift their metabolism based on their differentiation state and functional capacity: namely, T nave (Tn) and T memory (Tm) cells mainly rely on oxidative phosphorylation (OXPHOS) for their bioenergetic needs, whereas T effector (Te) cells, which are dominantly responsible for tumor killing, are fueled by glycolysis ( Redox metabolism, methionine metabolism, and the general control nonderepressible 2 (GCN2) pathway have all garnered increasing attention in the cancer immunotherapy field as potential therapeutic targets

Berglund, J