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In patients without cancer history, 14 primary cancers were observed [SIR: 0.71 (0.39, 1.20)]

Additional class-related concerns include: Gallbladder disease , including cholelithiasis (gallstones) and cholecystitis, as observed with GLP-1 receptor agonist medicines [27] Dehydration and acute kidney injury (AKI) risk secondary to significant gastrointestinal fluid losses Increased heart rate , a recognised class effect of GLP-1 receptor agonists Pancreatitis a potential risk that warrants prompt medical assessment if severe abdominal pain develops Thyroid C-cell tumours observed in rodent studies with GLP-1 receptor agonists

The growth factor stimulates tenocyte proliferation in a dose-dependent manner and maintains cell viability in serum-free conditions when combined with other growth factors

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