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Description

Lipid-engorged foamy macrophages that accumulate after traumatic SCI depend on PI3K activity to phagocytose myelin debris while simultaneously suppressing autophagic clearance of lipid droplets

These cells formed 3D spheres, which were embedded in Matrigel (Corning Inc.) and cultured in hIO medium [Advanced DMEM/F-12, 2% B-27, 100 ng/mL EGF, and 100 ng/mL Noggin]

Acknowledgements We would like to express our sincere gratitude to Professor Guoxun Chen at Huazhong Agricultural University for inviting us to write this review

doi: 10.1210/jc.2012-4262

This complement-dependent mechanism represents the primary pathogenic cascade responsible for ultrastructural damage at the neuromuscular junction in AChR-positive MG