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Such vascular responses are particularly relevant in experimental models of ischemia, where enhanced circulation contributes to tissue preservation and recovery.(22) In addition to its effects on vascular growth, it has been associated with regulation of vascular tone through interactions with nitric oxidedependent signaling mechanisms

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The Cu(II)/Cu(I) redox couple generates reactive oxygen species through the Fenton-like pathway: Cu(II) + O Cu(I) + O Cu(I) + HO Cu(II) + OH + OH Hydroxyl radicals (OH) are highly reactive and immediately oxidize susceptible amino acids