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Reviews often reflect individual experiences but lack scientific controls

Do GHKCu (copper tripeptide) topical formulations improve acne, and are they safe for use?

The review also noted that GHK-Cus copper complexation ability raises Cu2+ penetration rates across the stratum corneum, and documented the development of formulation innovations including the TriHex peptide system that combine GHK-Cu-type tripeptides with hexapeptides to produce synergistic upregulation of regenerative genes and suppression of aberrant collagen deposition

doi: 10.1007/s00467-004-1713-8 75 OhY

Headaches: Occasional mild headaches occur in some users, particularly during the first week