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Importantly, the majority of sulforaphanes neuroprotective effects are mediated by NRF2, since the absence of NRF2 prevents sulforaphanes effects (Innamorato et al., 2008

Marchi N, Granata T, Ghosh C, Janigro D

Vitamin C and nitrate medications: Taking nitrate medications can cause tolerance over time, meaning that your body gets used to the drug and it has less of an effect

ALS-causing mutations significantly perturb the self-assembly and interaction with nucleic acid of the intrinsically disordered prion-like domain of TDP-43